While some baddies are bigger reskins of earlier enemies, many have unique attack patterns, or at least combine moves you’ve seen before in hilariously punishing new ways.
Below is our ongoing list of Nioh 2 boss guides, collecting advice and strategies on how to beat most of the toughest bosses throughout the game.
We’ve stuck mostly to the bosses you’ll find in Nioh 2’s main missions, but there was one side mission fight I felt needed a page since it threw two tough enemies your way at once.
Generally with side missions though, you can return back to them later in the game when you’ve leveled up your character, and they’ll be really easy to brute force. If you’re stuck on a side mission boss, use a Divine Branch to retreat back to your Starting Point and come back later.
You do get a lot of Guardian Spirits by beating bosses in side missions though, so they’re worth doing at some point.
For a run-down of the weapons in Nioh 2, check out our page here. Or if you’re looking at maximising your character build, you can find that here.
Otherwise, check out our required boss guides. Each comes with an instructive video of me derping my way through on my first blind playthrough. I once had to borrow a pair of women’s gym gloves to beat a boss in Sekiro because my hands were too clammy - if I can do any of these bosses, so can you.
Nioh 2 Boss Guides in chronological order
How to beat the Mezuki How to beat the Enenra How to beat the Yatsu-no-Kami How to beat the Gozuki How to beat Saito Yoshitatsu How to beat the Kamaitachi How to beat Magara Naotaka How to beat Azai Nagamasa How to beat Saika Magoichi How to beat the Gyuki How to beat Kasha How to beat Ryomen Sakuna How to beat Maeda Toshile How to beat Shibata Katsuie How to beat Tokichiro How to beat the Daidara Bocci How to beat Shuten Doji
Nioh 2 Side Mission Guides
The Shiftling’s Wise Judgement
Nioh 2 Enemy Guides
How to beat the Enki How to beat the Ippon-Datara
